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Acid keeps the protein away from the pH at which its net charge is lowest and aggregation is most favorable, but it also means the concentrated stock is not at physiological pH and that transferring it into a buffered medium involves a pH transition where local precipitation can occur if it is done abruptly into a small volume
Glucagon and its receptor are present in a subpopulation of type II cells
Organic acid levels also tend to change quickly when our inputs change: a shift in diet or a new supplement can make a big difference
Common gastrointestinal effects include nausea (1520% of patients), vomiting, and early satiety, typically improving within weeks to months
Bibcode:2007PhyRv..87.1215B
