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Moreover, oxidation of AAT may lead to a loss of its anti-protease activity that is already lower in AATD, so the antioxidant potential in the treatment of emphysema patients with AATD needs to be considered

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High proportions reached clinically meaningful thresholds: up to 100% lost 5%, 93% lost 10%, and 83% lost 15% of body weight at higher doses

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