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The semaglutide cohort ( n = 668) compared with the non-GLP-1RA anti-obesity medications cohort ( n = 21,445) had a higher prevalence of adverse socioeconomic determinants of health, problems related to lifestyle, severe obesity, obesity-associated comorbidities and mental disorders

Critics correctly point out that animal studies have limitations for predicting human outcomes

Losing weight can be challenging

What the date should change is your timeline: the window to plan a transition on your own schedule, with labs and a provider involved, is open now and will feel much shorter once the rule is finalized

Ideal candidates are women with documented metabolic dysfunction, insulin resistance, or overweight/obesity alongside endometriosis, where weight management may provide secondary benefit