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Histamine is primarily metabolized via methylation and Phase 2 liver detoxification, both of which are heavily dependent on adequate glutathione availability

Cagrilintide, Cagri[P37Y] and the analogue CagriBB lacking the N-terminal lipidation were obtained from Novo Nordisk

At functional gene level, we observed a net decrease in the microbial potential to metabolize amino acids, likely as a direct consequence of the lower amino acid availability at caecal level, as linked to the increased nitrogen retention

Yin SC, Ji P, Wu C, Jin H, Qian