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Pruritus in primary myelofibrosis: management options in the era of JAK inhibitors

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Real world experience has demonstrated patients supplementing semaglutide with targeted nutrition and resistance exercise maintain more lean mass, lose more visceral fat, and achieve superior long-term metabolic outcomes than drug or lifestyle alone

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This is achieved by inhibiting the protein PTEN and activating the PI3K/AKT/mTOR and PI3K/AKT/GSK3 pathways, as well as preventing the movement of vascular smooth muscle cells (Figure 2) (32, 33)

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