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This phenomenon is predominantly caused by cobalamin release during hepatic cytolysis and/or decreased cobalamin clearance by the affected liver
The effects of alcohol poisoning can be extremely dangerous and, in some cases, life-threatening
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The NHS advises that taking up to 2mg (2000 micrograms) daily of vitamin B12 supplements is unlikely to cause harm, with no established upper limit in the UK
Clinical trials commonly start with 1 mg weekly and gradually increase the dose to higher levels such as 4 mg, 8 mg, or even 12 mg depending on the study protocol
However, your treatment depends on the severity of vitamin B12 deficiency (whether you need B12 injections or B12 oral supplements)
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