Researchers examine how KPV blocks the nuclear translocation of Nuclear Factor kappa B (NF-$\kappa$B) in both intestinal epithelial cells and active immune cells, subsequently shutting down the transcription and downstream secretion of damaging pro-inflammatory cytokines such as TNF-$\alpha$, IL-1$\beta$, and IL-6
By downregulating the production of inflammatory mediators like TNF- and IL-6, lycopene acts as a systemic anti-inflammatory, helping to soothe the aching, heavy sensation in the limbs
It is more effective compared to dulaglutide and Semaglutide, with fewer gastrointestinal side effects
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