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Thyroid replacement (levothyroxine) absorption can be affected by GLP-1-induced slower gastric transit, so spacing doses 4+ hours apart from oral semaglutide or tirzepatide is recommended

Retatrutide adds glucagon receptor activation to the dual GLP-1/GIP activation that tirzepatide provides

Appetite control Second, it acts on appetite centres in the brain, particularly in the hypothalamus, reducing hunger signals and dampening food cravings

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