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Tregs are responsible for maintaining immune homeostasis by suppressing overactive immune responses, preventing autoimmune reactions, and ensuring tolerance to self-antigens [321]

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The replacement of the C-terminal tail of GIPR with that of GLP-1R significantly increased the rate of receptor endocytosis, which could suggest that this region of the receptor may be involved in GIPRs reported constitutive recycling

Ussing chamber study Nonfasted mice were dissected under isoflurane anesthesia, and the cecal tissue was removed and washed well with Krebs Ringer solution (117 mM NaCl, 5.9 mM KCl, 2.5 mM CaCl 2 , 1.2 mM MgCl 2 , 24.8 mM NaHCO 3 , 1.2 mM NaH 2 PO 4 , and 11.1 mM glucose)

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