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When normality was met and there were unequal variances, a Welchs t -test, a Welchs one-way ANOVA or an adjusted Welch version of the two-way ANOVA using trimmed means was used when testing two groups, more than two groups with one variable or two independent variables, respectively 52

Severe or worsening pain that intensifies rather than improves over 48 to 72 hours may indicate an injection site complication requiring assessment

Adverse events outcomes (n = 21,229) were reported including 1,039 deaths (4.9% of all reports), 1,613 life-threatening events (7.6%), and 7,426 hospitalizations (35%)

Refrigerate reconstituted AOD-9604 at 2-8 degrees Celsius (35-46 degrees Fahrenheit)