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Further studies have reported that exposure to GHRP-2 in laboratory settings may induce a significant increase in peak GH levels, mean pulsatile GH secretion by the anterior pituitary gland cells, and may potentially upregulate mediators of GHs anabolic actions such as insulin-like growth factor-1 (IGF-1): In one trial, GHRP-2 was suggested to induce up to 181-fold higher spike in GH production by the anterior pituitary gland cells