Using the Drosophila melanogaster model, Liu et al
MuthuKathija M, Sheik Muhideen Badhusha M, Rama V (2023) Green synthesis of zinc oxide nanoparticles using Pisonia Alba leaf extract and its antibacterial activity
Results showed berberine reduced body weight by 2.05 kg (approximately 4.5 pounds) and BMI by 1.04 kg/m compared to placebo or lifestyle intervention alone
Most people see a surge of weight loss early in their protocols, after completing titration
In the authors anecdotal experience, when further uptitration is not tolerated, but treatment effects are noted, maintaining the patient at the lower tolerated dose may be preferable to discontinuation
This leads to unpredictable results and potential side effects from contaminants