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[53] The substitution of the alanine prevents chemical breakdown by dipeptidyl peptidase-4
76 , S6S19 (2024)
Sources: SURMOUNT-5 Clinical Trial (May 2025, The first head-to-head trial comparing the efficacy and safety of tirzepatide versus semaglutide for obesity management, detailing differences in total weight reduction
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One key reason is a rise in appetite once treatment ends
Key takeaways Both peptides boost growth hormone naturally, but Ipamorelin targets specific receptors while Sermorelin mimics natural hormone release
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