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The evidence base was dominated by preclinical animal and mechanistic investigations, while human clinical outcome data were limited and largely observational

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This is information we did not have before and it should be included in discussions between patients and their doctors, especially if patients have other known optic nerve problems like glaucoma or if there is pre-existing significant visual loss from other causes. Graham McGeown, honorary professor of physiology at Queens University Belfast, said: This research does suggest an association between semaglutide treatment and one form of sight-threatening optic neuropathy, but this would ideally be tested in larger studies