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Int J Radiat Oncol Biol Phys 18:10691075
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Human GSTs are of interest because tumour cells show increased levels of expression of single classes of GSTs, which leads to drug resistance
Potential Risks and Side Effects While glutathione treatments are generally considered safe, some individuals may experience side effects, including: Allergic reactions (rare) Low blood pressure (with IV administration) Gastrointestinal issues, such as nausea or diarrhea (more common with oral supplements) It is essential to consult with a healthcare professional before starting any glutathione treatment, especially for individuals with underlying health conditions or those who are pregnant or breastfeeding
This suggests that the decreased A1AT concentration, coupled with exacerbated inflammatory processes and heightened oxidative stress observed in T21 pregnancies, may have a negative impact on multiple comorbidities, potentially contributing to the development of the DS phenotype (Buczyska et al