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When blood glucose (BG) concentrations are normal or high, the intestines secrete GLP-1 and GIP to act on pancreatic beta cells through intracellular signaling pathways that involve cyclic adenosine monophosphate (cAMP)
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m-GPx4 is mainly expressed in both rostral and caudal neural tube (rnt and cnt) in early stage and at forebrain (fb), midbrain (mb), and hindbrain (hb) in later stages
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Since L-glutamine has a major role in intestinal health, we discussed how L-glutamine might improve tight junction functions, gut microbiome, immunity, and inflammatory conditions in SCD to provide the benefits against VOC
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