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Drinking water can help with any discomfort and support your metabolism

After 4-6 weeks at the reduced dose, titrating back up may produce improved effects

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In rare cases, dehydration can contribute to acute kidney injury, particularly in people with underlying kidney disease or those unable to maintain adequate hydration

One case report described a 51-year-old female with no history of diabetes or excessive alcohol use who presented to the ED with altered general status, nausea, vomiting, deep asthenia, and articular pain after engaging in a 4-day restrictive diet followed by 48 hours of fasting