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An orally active catalytic metalloporphyrin protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in vivo

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While capsules can be administered by mouth to pigs, it was decided to introduce the capsule directly into the jejunum, since the gastric transit in the pig can be variable and of long duration, the pig stomach is more fermenting than that of a human, and the pH of the stomach is high, to the extent that enteric coating of the capsule may not give adequate protection

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