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Malignant melanoma should be first excluded because of its poor prognosis
Moreover, GLP-1 RAs can cross the bloodbrain barrier and target key hypothalamic nuclei involved in energy homeostasis 17,18,19
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Specifically, Rybelsus (oral semaglutide) has been shown to lower A1C by about 1.0% to 1.5%, while Foundayo (orforglipron) reported average A1C reductions ranging from about 1.2% to 1.7% depending on the dose
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