Suitable for studies involving GLP-1 receptorrelated pathway characterization and method development in model systems.Not for human use
Phytochemicals such as, the Resveratrol (3,4,5-trihydroxy stilbene) and the Curcuminoids (with , -unsaturated carbonyl groups) are potential inducers of HO-1 expression through Nrf2/ antioxidant-responsive element (ARE) pathway 471,472
Similarly, Adikwu and Bokolo 43 recorded a significant rise in MDA level and a significant decline in GSH level and SOD, CAT and GPx activities in the kidney tissue of MTX-treated rats, and they attributed these results to free radicals production, which might be the probable reason for the reduction of the anti-oxidant activities
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In control rats, GSH increased while GSSG did not significantly change [53]