Renue is confident enough in these tablets' ability to bypass hepatic metabolism that it's willing to underdose them significantly, but how that translates to NMN in the bloodstream, and eventually intracellular NAD+, is unclear, creating question marks for both safety and efficacy
Its worth being direct here: most of this evidence comes from preclinical and early-stage research rather than large human trials
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The distinction matters for both safety and legality
10.1089/ARS.2009.2695 69 MatobaK.DohiE.ChoiE
Oral formulations are designed to survive the stomach acid and are better suited for addressing systemic inflammation and gastrointestinal issues like ulcers or inflammatory bowel disease