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Rapid intracellular turnover occurs with a half-life of about 24 hours

Downstream observations in models include transcriptional changes consistent with enhanced mitochondrial function and lipid utilization

However, the relative abundance of the genus Parasutterella , commonly decreased by HFD 61 , was increased in both the 5A-1MQ- and vehicle-treated mice switched from WD to LD, and the abundance of Parasutterella in all mice exhibited several correlations the EWAT metabolome

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