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In a small-scale four-week long, open-label study involving 14 individuals diagnosed with major depressive disorder and bipolar disorder, which also displayed impaired executive function, treatment with liraglutide significantly reduced Hamilton Depression Rating Scale (HDRS) scores and improved executive function, however, at the same time it did not improve cognitive function in patients [122]
United European Gastroenterology Journal
Combining two agents that each need their own titration stacks those dose-related effects, and no monitored study has characterised where the resulting ceiling sits
Unlike older compounds in the same class, it has relatively little activity on: Cortisol secretion Prolactin secretion Appetite stimulation This selectivity is one reason it remains popular in peptide protocols