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Edited by Professor Alessandro Finazzi-Agr Supplementary information Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made

As a naturally occurring growth factor, IGF-1 plays crucial roles in muscle development, fat metabolism, and cellular repair throughout your body

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Lessons to learn for adequate targeted therapy development in metastatic colorectal cancer patients