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Several critical questions remain unresolved: (1) most existing studies are confined to animal and cellular models, with a notable lack of large-scale population-based investigations and clinical validation, thereby impeding translational application

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Thus, our results not only have potentially important mechanistic implications in how both the oxidative and antioxidant arms of redox homeostasis cooperate to regulate cell survival and death, but also provide a promising therapeutic strategy for cancer patients harboring oncogenic RAS that warrants further translational and clinical investigation