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SURMOUNT-4: placebo group regained +14.0% body weight over 52 weeks, with only 16.6% maintaining 80% of loss
In accordance with the pivotal role of mitochondria in steering differentiation processes by balancing OXPHOS and glycolysis, compromised mitochondrial function in ClpP IEC mice, as well as ex vivo inhibition of OXPHOS in organoid cultures, was sufficient to impair EEC development
& Zarrindast, M
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The cardiovascular biology of glucagon-like Peptide-1
GLP-1 is secreted from these cells in response to nutrient ingestion 11
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