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While these three systematic reviews offer some promising evidence, the study methods varied greatly among the individual studies, and the amount of weight loss was small

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Its reasonably well supported by studies abroad and has a good safety profile when used appropriately

Sitagliptin and Metformin Co-administration in Patients with Type 2 Diabetes Inadequately Controlled on Diet and Exercise Table 1 summarizes the most common (5% of patients) adverse reactions reported (regardless of investigator assessment of causality) in a 24-week placebo-controlled factorial study in which sitagliptin and metformin were co-administered to patients with type 2 diabetes inadequately controlled on diet and exercise

Drink 12-16 oz of water upon waking, before any food or medication Drink 8 oz of water 30 minutes before each meal Drink 8 oz of water 2 hours after each meal Drink 8 oz of water before bed Total minimum: 64-80 oz per day, more if exercising or in hot weather Set phone reminders

After reconstitution with bacteriostatic water, the solution should be refrigerated and used within 28-30 days