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The search for medications to treat obesity has expanded to include other nutrient stimulated hormones (NuSH), such as glucagon and amylin [5, 6], as discussed below

They reduce inflammation by suppressing markers like CRP and TNF-, promote weight loss, lower blood pressure, improve lipid profiles, and enhance endothelial function

It can irritate the stomach lining and amplify nausea that might otherwise have stayed mild

In the SUSTAIN 8 study, patients with T2DM exhibited a lean mass decrease of 2.3 kg alongside a total weight loss of 5.3 kg, resulting in 43.4% of weight loss attributable to lean mass, while the ratio of lean mass to total mass increased by 1.2% from the baseline [111]

It is primarily involved in red blood cell formation and DNA synthesis

Examples of -blockers included but were not limited to propranolol and metoprolol