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Remove the needle and dispose of the syringe in your sharps container

The dose is gradually increased over 16 weeks to minimise gastrointestinal side effects and allow the body to adjust, as outlined in the MHRA/EMC Summary of Product Characteristics

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Semaglutide works exclusively through the GLP-1 pathway, which still produces meaningful appetite reduction but operates through a single mechanism

This helps ensure they are not using materials from questionable sources

The presence of chronic hyperglycemia, insulin resistance, oxidative stress, and pro-inflammatory mechanisms contribute to endothelial dysfunction in patients with diabetes mellitus (61)