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10.1124/jpet.111.188136 27 KikkawaY

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Mechanistically, E2F1-mediated CHAC1 upregulation promotes PKM2 SUMOylation enabling PKM2 nuclear translocation or kinase activation ( CHAC1s contribution to tumor progression is markedly influenced by the cellular and tumor context, differing across various cancer types

An instant vascular inflammatory response, though initially protective against such threats, can become detrimental if excessive or chronic