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In the LEADER trial, a total of 9,340 subjects with T2D and high CV risk were randomized to liraglutide or placebo and followed-up for a median of 3.8 years (100)

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Levodopa, the most potent symptomatic therapy, markedly improves motor symptoms, yet it comes with considerable adverse reactions ( As early as 1982, glutathione peroxidase 4 (GPX4) was reported to inhibit the accumulation of lipid hydroperoxides, thus preventing plasma membrane damage ( - system) and shared several characteristics with ferroptosis, including reactive oxygen species (ROS) accumulation and high lipoxygenase enzymatic activity ( - system overexpression ( Figure 1 )