The latest body to take action on this is the Medicines and Healthcare Products Regulatory Agency (MHRA) in the United Kingdom, which recently updated its guidance on these weight loss jabs, citing a rise in cases of acute pancreatitis reported to the Yellow Card scheme, which monitors adverse reactions to medications
First, due to the small number of included studies, the reported data at each follow-up time point after treatment discontinuation were limited and fewer studies were included in sensitive analyses, reducing the power of the test
Weight gain on semaglutide typically results from subtherapeutic dosing, genetic variations reducing GLP-1 receptor sensitivity, medication tolerance, non-adherence, or insufficient calorie deficit despite appetite suppression
Side effects are primarily gastrointestinal
Balance or flexibility session (15-20 mins)
And some of the rats did show potentially premalignant changes in their pancreases on these drugs