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(6) Heike Stier, Evert Vos, David Kenley (2013) Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans Journal of Endocrinology and Metabolism, 2013, Volume 3 (Issue 1-2), Pages 7-15

doi:10.1111/1755-5922.12064

No antibody formation When the immune system recognizes a foreign protein and produces antibodies against it, this can reduce the compound effectiveness over time and potentially cause allergic reactions

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The absence of toxicity in a 90-day rat study is a positive signal, but it's not a guarantee of human safety at equivalent timescales

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