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In SOUL, composite HF endpoints were analysed as a secondary outcome, with oral semaglutide resulting in a non-significant reduction in HF events

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Specifically, ischemia activates T-type calcium channels, leading to a swift accumulation of intracellular calcium ions, which in turn causes excitotoxicity and apoptosis (Park et al., 2013

Future oral versions of these medications still in the pipeline are also set for preferential pricing initial doses around US $150/month once approved