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Phase 2 trial (NEJM 2023) reported 24.2% mean weight loss at 48 weeks with 12 mg/week retatrutide, with gastrointestinal adverse events rising sharply at the 8 mg and 12 mg doses

Additionally, ingestion of non-ethanol alcohols, such as methanol or isopropanol, found in products like antifreeze or certain solvents, causes severe poisoning