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Available from: A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Who Have Obesity or Are Overweight (SURMOUNT-2)
What trials do show is that higher doses are linked to stronger side effects, especially digestive ones
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Retatrutide's triple receptor activity creates a more complex pharmacological picture than single-agonist GLP-1s, and individual factors including your current dose, your side effect history, your training schedule, your sleep patterns, and any concurrent medications all shape what the right timing looks like for your specific situation
Pooled estimates derived from the included reviews are shown in Supplementary Figures S8, S9
This dual mechanism affects both its efficacy and its timing requirements
