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Renoprotective effect of erythropoietin via modulation of the STAT6/MAPK/NF-B pathway in ischemia/reperfusion injury after renal transplantation

Although the hypotensive effect of GLP-1 RAs seems to be manifested by BW losing, other mechanisms not related to BW might be implied by the mediation meta-analysis, which suggests an existence of BW-independent hypotensive effect of GLP-1 RA, along with the clinical evidence of weak or no correlations, and difference in time course between BP lowering and BW reducing effects

GLP-1 infusion results in decrease insulin demands

GLP-1R are also widely expressed in brainstem and hypothalamic regions implicated in appetite control (90)

They can be helpful for some patients, but expectations should be realistic

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