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In May 2026, Lilly reported that in a late-stage trial of adults with obesity or overweight and at least one weight-related comorbidity, the highest 12 mg dose of retatrutide produced 28.3% average weight loss over 80 weeks, and more than 45% of participants lost 30% or more of their body weight

Thus, cystine starvation induces a stress signal of amino acid limitation through GCN2-eIF2-ATF4 branch in the ISR but not ER stress in HepG2 cells