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These medications are generally well-tolerated, with common side effects including nausea, vomiting, and diarrhea

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Early clinical trial data have demonstrated weight loss approaching 2530% of body weight in some patients, making it one of the most promising obesity treatments currently under investigation

The fast form of 2M arises through a conformational change caused by entrapment of a protease in the 2M bait region, or chemical cleavage of an internal thiol ester bond located near the bait region 17