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The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

This regulation occurs at multiple levels: Genetic Regulation : Genes encoding the enzymes of the carnitine biosynthetic pathway are subject to transcriptional regulation by factors responsive to metabolic needs

In preclinical research, this mechanism has been associated with selective apoptosis of senescent cells while preserving healthy cellular populations

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We also report that 13% of patients with type 1 diabetes in our registry use adjuvant glucose-lowering therapy in addition to insulin, significantly higher than the 5.4% reported from the T1D Exchange Registry in the US [18]

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