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4.2 Dysbiotic microbiome stimulates cyclooxygenase-2 expression, affects gastric emptying, and induces GERD Cyclooxygenase-2 (COX-2) is the rate-limiting enzyme that catalyzes the initiating step in the metabolism of arachidonic acid to prostaglandin H2 and is a precursor to prostaglandins such as prostaglandins, thromboxanes, and prostacyclins, which act as autocrine and paracrine lipid mediators in the maintenance of local homeostasis by mediating vascular function, wound healing, and inflammation (52)

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Today, most people experiencing this effect are already taking semaglutide or tirzepatide for diabetes or weight management

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Our providers take those changes into account when personalizing your plan

Its primary biological function involves transporting long-chain fatty acids into mitochondria, where they undergo beta-oxidation to produce cellular energy