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Less commonly, GLP-1 medications carry warnings for more serious risks, including pancreatitis, gallbladder problems, and possible thyroid tumors

A systematic review found that hair loss associated with GLP-1 receptor agonist use is a documented phenomenon, primarily related to the telogen effluvium triggered by rapid weight loss and nutritional deficiency rather than a direct drug effect

Retatrutide achieved up to 24.2% body weight reduction over 48 weeks in the Phase 2 trial published in the New England Journal of Medicine , which involved adults with obesity but without diabetes

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Since the start of 2025, OZEM is up 28.62%, sharply outpacing the S&P 500 Health Care Sector (8.55%) and the broader S&P 500 Index (12.76%)