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Unlike many diabetes medications, Metformin doesn't increase insulin secretion

doi: 10.1038/s41380-018-0283-2

Anyone who suspects they have experienced an adverse reaction to any medicine or substance licensed or otherwise should report it to the MHRA via the Yellow Card scheme (yellowcard.mhra.gov.uk)

Ganipisetti VM, Bollimunta P

While full cardiovascular outcomes are pending, early findings are very encouraging

Disruption of IL-24 increases cell death in APAP-stimulated mouse hepatocytes, significantly decreased levels of IL-24 in patients with clinical ALF may be associated with disease progression, thus IL-24 is a potential biological indicator of prognosis or therapeutic intervention in patients with liver injury [206]