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In some cases, switching to a different GLP-1 agent or adjusting the dosing schedule may provide better tolerability
Patients were randomized 1:1:1:1 to survodutide 2.4, 4.8, or 6 mg weekly, or placebo for 48 weeks
HR = 1.18
As GLP-1Rs are expressed in multiple brain regions, and GLP-1RAs such as liraglutide and lixisenatide can penetrate the blood-brain barrier, liraglutide and exendin-4 can be vagus-dependent or independent in the suppression of the food intake (176)
Reports include very fast heart rate, high blood pressure, severe anxiety, and muscle pain that feels out of proportion to what you did that day
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