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The ANTHEM-UC study (NCT06049017) is a Phase 2b multicenter, placebo-controlled, dose-ranging RCT evaluating three once-daily oral doses of icotrokinra versus placebo in 252 adults with moderately to severely active UC who had inadequate response or intolerance to conventional therapy, prior biologics, or JAK inhibitors, with the primary endpoint being clinical response at Week 12 (defined as 30% and 2-point decrease in mMS with rectal bleeding improvement)
