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CYP-450, cytochrome P450 enzyme system
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This bidirectional regulation suggests that the two systems evolved to work together, and that disrupting one (as happens in menopause) impairs the other
Guidelines from the American Diabetes Association and the European Association for the Study of Diabetes recommend GLP-1 medications as preferred agents for patients with atherosclerotic cardiovascular disease, heart failure, or chronic kidney disease
Taken together, these heterogeneous findings highlight both biological plausibility and the methodological constraints that shape the current evidence base, motivating the integrative Discussion below
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