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Importantly, direct pharmacologic inhibition of FAO showed similar effects (suppressed IL-1 and IL-6 expression), with a decrease in pathologic lung damage in animal models of infection (87)

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These glucose improvements result from multiple mechanisms: enhanced insulin secretion through GLP-1 and GIP receptor activation, improved insulin sensitivity in peripheral tissues, and optimized hepatic glucose production through balanced glucagon signaling

Each adjustment is an opportunity to reinforce lifestyle strategies: emphasizing nutrient-dense foods with volume (without excess calories), monitoring muscle preservationand ideally muscle gainwhile on GLP-1 / GIP therapy

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