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If your research hypothesis involves dose-response relationship testing, include at least three dose groups (low, medium, high) with vehicle control rather than escalating within a single group
This helps produce short-chain fatty acids (SCFAs) and eventually stimulates GLP-1 release
Rotating sites minimizes this
10.1111/j.1460-9568.2005.04038.x 50 ImperatoA.Di ChiaraG
It is also worth refining clauses and adding penalty fees in case of unmet timelines or quality issues
Based on clinical trial criteria, candidates typically include adults with obesity (BMI 30) or those with a BMI 27 plus weight-related health conditions such as type 2 diabetes, cardiovascular disease, or kidney disease
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