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specifically, the end-product, GSH, accumulates in the cell and acts as an inhibitor of -glutamylcysteine ligase activity, thereby preventing the overproduction of GSH 41 (Figure 2)

, Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation, Am

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Undermethylation may represent one contributing or modifying pattern in a subgroup of patients