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Safety signals of special interest, including pancreatitis, gallbladder events, neoplasms, and suicidal ideation, were adjudicated by blinded expert committees

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Combining two agents that each need their own titration stacks those dose-related effects, and no monitored study has characterised where the resulting ceiling sits

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Acta Biochim Biophys Sin 56:1311 Liu F, Ding D, Wang Y, Liu S, Peng C, Shen F et al (2023) Icariin as a potential anticancer agent: a review of its biological effects on various cancers